Article

Cryo-EM structure of Alzheimer’s disease tau filaments with PET ligand MK-6240

2023-09-22

Abstract excerpt

Positron Emission Tomography (PET) ligands have advanced Alzheimer’s disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identified AD brain tissue with elevated tau burden, purified filaments, and determined the structure of second-generation high avidity PET ligand MK-6240 at 2.31 Å resolution, which bound at a 1:1 ratio within the cleft of tau paired-helical filament (PHF), engaging with...

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Literature Corpus work: b2127005-232f-5073-8f2d-25079c512901
DOI: 10.1101/2023.09.22.558671

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