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Article

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments.

eLife - 20 May 2026

Lövestam Sofia, Wagstaff Jane L, Katsinelos Taxiarchis, Shi Jenny, Freund Stefan M V, Goedert Michel, Scheres Sjors H W

Abstract excerpt

The assembly of tau into amyloid filaments is associated with more than 20 neurodegenerative diseases, collectively termed tauopathies. Electron cryo-microscopy (cryo-EM) structures of brain-derived tau filaments revealed that specific structures define different diseases, triggering a quest for the development of experimental model systems that replicate the structures of disease. Here, we describe 12...

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Identifiers

PMID: 42159330
DOI: 10.7554/eLife.104778
PMCID: PMC13189620

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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