Article

Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

2024-10-23

Abstract excerpt

The assembly of tau into amyloid filaments is associated with more than twenty neurodegenerative diseases, collectively termed tauopathies. Cryo-EM structures of brain-derived tau filaments revealed that specific structures define different diseases, triggering a quest for the development of experimental model systems that replicate the structures of disease. Here, we describe twelve phosphomimetic, serine/threoni...

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Literature Corpus work: a96e197e-a1bc-5b3f-a750-8bbd7c5a4ffc
DOI: 10.1101/2024.10.23.619846

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