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History shapes regulatory and evolutionary responses to tigecycline in strains of <i>Acinetobacter baumannii</i> from the pre- and post-antibiotic eras

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Evolutionary history encompasses genetic and phenotypic bacterial differences, but the extent to which history influences drug response and antimicrobial resistance (AMR) adaptation is unclear. Historical contingencies arise when elements from an organism’s past leave lasting effects on the genome, altering the paths available for adaptation. We utilize strains isolated before and after widespre...

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Literature Corpus work
b2078a33-359e-54ac-bb04-de7067ba6bb2
DOI
10.1101/2025.01.22.634413
Open publication

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History shapes regulatory and evolutionary responses to tigecycline in strains of <i>Acinetobacter baumannii</i> from the pre- and post-antibiotic erasDOI 10.1101/2025.01.22.634413
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