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Article

Mutations in two-component signaling systems drive experimental evolution of tigecycline and colistin resistance in Acinetobacter baumannii.

Antimicrobial agents and chemotherapy - 10 Dec 2025

Kent J E, Elane M, Leyn S, Zlamal J, Wong N, Aizin M, Zampaloni C, Louvel S, Haldimann A, Vercruysse M, Osterman A

Abstract excerpt

The treatment of infections by Acinetobacter baumannii, a clinically significant nosocomial gram-negative bacterial pathogen, is hampered by antibiotic resistance, which is exacerbated by its exceptional genetic plasticity. Knowledge of the dynamics and mechanisms underlying the acquisition of antibiotic resistance is essential for the proper stewardship of their utilization. Here, we used a continuous culture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41159736
DOI: 10.1128/aac.00809-25
PMCID: PMC12691633

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