Article

Treatment history shapes the evolution of complex carbapenem-resistant phenotypes in <i>Klebsiella</i> spp.

2022-08-30

Abstract excerpt

<h4>ABSTRACT</h4> Antibiotic resistance is driven by selection, but how a bacterial strain’s evolutionary history shapes drug-resistance remains an open question. Here we reconstruct the genetic and evolutionary mechanisms of carbapenem resistance in a clinical isolate of Klebsiella . A combination of short and long read sequencing, machine learning, genetic and enzymatic analyses established that this carbapene...

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Literature Corpus work: 226a32b2-d443-52d2-8b07-b4e28a36aeca
DOI: 10.1101/2022.08.30.505938

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