Article

Identification of Evolutionary Trade-Offs Associated with High-Level Colistin Resistance in <i>Acinetobacter baumannii</i>

2025-01-18

Abstract excerpt

<h4> ABSTRACT </h4> Colistin (COL) belongs to the polymyxin group of drugs which possesses a positive charge and interacts with lipopolysaccharide (LPS) of Gram-negative bacterial outer membrane. Additionally, it can penetrate the cell membrane and disrupt the integrity of the phospholipid leading to cell death. Resistance against COL has been reported in Acinetobacter baumannii , a bacteria in the ‘ESKAPE’ gro...

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Literature Corpus work: 5b3d2f34-7607-5831-95e2-0e86f354992d
DOI: 10.1101/2025.01.17.633615

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