Article
Epigenetic modifications and metabolic gene mutations drive resistance evolution in response to stimulatory antibiotics.
Molecular systems biology - 1 Mar 2025
Lin Hui, Wang Donglin, Wang Qiaojuan, Mao Jie, Yang Lutong, Bai Yaohui, Qu Jiuhui
Abstract excerpt
The antibiotic resistance crisis, fueled by misuse and bacterial evolution, is a major global health threat. Traditional perspectives tie resistance to drug target mechanisms, viewing antibiotics as mere growth inhibitors. New insights revealed that low-dose antibiotics may also serve as signals, unexpectedly promoting bacterial growth. Yet, the development of resistance under these conditions remains unknown....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.