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Resistance associated genomic variations for moderate level tigecycline resistance evolution in Acinetobacter baumannii.

World journal of microbiology & biotechnology - 4 Apr 2026

Acharya Kusumita, Biswas Shatarupa, Bhattacharyya Sayani, Ghosh Mallika, Bhattacharya Arijit

Abstract excerpt

Among the last-resort antibiotics, tigecycline is a semisynthetic drug derivative of tetracycline used in medical facilities, resulting in tigecycline-resistant Acinetobacter baumannii (TRAB) strain development. Recent reports suggested the emergence of heteroresistance, intermediate-resistance, and resistance strain development against the tigecycline of A. baumannii isolates, causing treatment failure in...

Topics

Tigecycline
Acinetobacter baumannii
Anti-Bacterial Agents
Microbial Sensitivity Tests
Mutation
Drug Resistance, Bacterial
Bacterial Proteins
Whole Genome Sequencing
Genome, Bacterial
Biofilms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Evolution, Molecular

Methyltransferases

Erythromycin

Azithromycin

Drug Resistance, Multiple, Bacterial

Source

Identifiers

PMID: 41933192
DOI: 10.1007/s11274-026-04908-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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