Article

Directed evolution of a compact TranC11a system for efficient genome editing

2025-09-28

Abstract excerpt

The recently discovered TranC systems represent programmable RNA-guided DNA endonucleases of transposon origin with compact protein sizes ideal for therapeutic delivery. However, their editing efficiency in human and plant cells is limited. Here, we evolved TranC11a and engineered its sgRNA to enhance overall editing efficiencies. TranC11a systems exhibit up to 9.2-fold higher editing activity than its parent and...

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Literature Corpus work: b205d2bd-3bcb-5009-a82a-0e3047f79ee0
DOI: 10.1101/2025.09.28.678669

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