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Article

CasY7: An optimized Cas12i system for enhanced genome editing in monocot crops.

Journal of integrative plant biology - 1 Sept 2026

Zhong Dating, Dong Yanxiao, Pan Hong, Fu Yanan, Zhao Yining, Ruan Shuting, Yu Wencong, Wang Yiwen, Yin Qianlan, Zhang Yanfei, Huang Yisen, Shen Jiaqi, Zhang Hongling, Wu Yuxuan, Xu Jieting, Lu Yuming

Abstract excerpt

The CRISPR-Cas12 family nucleases, particularly the Cas12i subtypes, are considered promising alternatives to Cas9 for genome editing in plants. We previously developed a new Cas12i variant, CasY7, which has been successfully applied in clinical trials; its performance in plants remains to be investigated. Initial testing in stable transgenic maize and rice showed that the codon-optimized CasY7 (pCasY7e1)...

Read the complete abstract on PubMed

Topics

Zea mays
Plants, Genetically Modified
Oryza
CRISPR-Cas Systems
Genome, Plant
Crops, Agricultural

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Gene Editing

Triticum

Mutation

CRISPR-Associated Proteins

Base Sequence

Source

Open in PubMed Open full text

Identifiers

PMID: 41814562
DOI: 10.1111/jipb.70181
PMCID: PMC13545833

Provenance

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