Article

Programmable RNA base editing with a single gRNA-free enzyme

2021-08-31

Abstract excerpt

<h4>ABSTRACT</h4> Programmable RNA editing enables rewriting gene expression without changing genome sequences. Current tools for specific RNA editing dependent on the assembly of guide RNA into an RNA/protein complex, causing delivery barrier and low editing efficiency. We report a new gRNA-free system, RNA editing with individual RNA-binding enzyme (REWIRE), to perform precise base editing with a single enginee...

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Literature Corpus work: 07a47a53-0318-5f3e-82f6-7b260e39c916
DOI: 10.1101/2021.08.31.458316

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