Article

Programmable Protein Stabilization with Language Model-Derived Peptide Guides

2024-07-26

Abstract excerpt

<title>Abstract</title> <p>Dysregulated protein degradation via the ubiquitin-proteasomal pathway can induce numerous disease phenotypes, including cancer, neurodegeneration, and diabetes. Stabilizing improperly ubiquitinated proteins via target-specific deubiquitination is thus a critical therapeutic goal. Building off the major advances in targeted protein degradation (TPD) using bifunctional small-molecule deg...

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Literature Corpus work: b1eb70ee-908c-5115-8aa8-eef7bf21521c
DOI: 10.21203/rs.3.rs-4670386/v1

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