Breaking Bad Proteins – Discovery Approaches and the Road to Clinic for Degraders

Abstract excerpt

Proteolysis Targeting Chimeras (PROTACs) describe compounds that bind to and induce degradation of a target by simultaneously binding to a ubiquitin ligase. More generally referred to as bifunctional degraders, PROTACs have led the way in the field of targeted protein degradation (TPD) with several compounds currently undergoing clinical testing. Alongside bifunctional degraders, single-moiety compounds, or molecu...

Topics

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• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

6f8dfec8-6ee4-56b3-a69a-25b9a2b2061c

DOI

10.20944/preprints202402.0637.v1