Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations <i>in vitro</i> and <i>in vivo</i>

Abstract excerpt

<h4>ABSTRACT</h4> Aberrant activation of Wnt signaling results in unregulated accumulation of cytosolic β-catenin, which subsequently enters the nucleus and promotes transcription of genes that contribute to cellular proliferation and malignancy. Here, we sought to eliminate pathogenic β-catenin from the cytosol using designer ubiquibodies (uAbs), chimeric proteins composed of an E3 ubiquitin ligase and a target-...

Topics

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• Chemical Synthesis and Analysis
• Click Chemistry and Applications
• Monoclonal and Polyclonal Antibodies Research
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

146e865c-73dd-52c4-80f8-91c5a92aba83

DOI

10.1101/2024.11.10.622803