Article

Modular RNA-based PROTACs for selective degradation of multidomain RNA-binding proteins

2025-11-03

Abstract excerpt

<title>Abstract</title> <p>RNA-binding proteins (RBPs) are central regulators of gene expression, yet their modular and dynamic architectures have hindered efforts to pharmacologically target them. The splicing factor RNA Binding Motif 39 (RBM39) is an attractive anti-cancer target, currently addressed by aryl sulfonamides that act as molecular glues to promote DCAF15-dependent degradation. However, their clinica...

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Literature Corpus work: 36df666c-fa12-5490-ab1d-f67cd1fc0020
DOI: 10.21203/rs.3.rs-7991452/v1

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