Article

A generative framework for enhanced cell-type specificity in rationally designed mRNAs

2024-12-31

Abstract excerpt

mRNA delivery offers new opportunities for disease treatment by directing cells to produce therapeutic proteins. However, designing highly stable mRNAs with programmable cell type-specificity remains a challenge. To address this, we measured the regulatory activity of 60,000 5’ and 3’ untranslated regions (UTRs) across six cell types and developed PARADE (Prediction And RAtional DEsign of mRNA UTRs), a generative...

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Literature Corpus work: 8ae8ee31-5841-59e4-a3aa-896a6718eeed
DOI: 10.1101/2024.12.31.630783

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