Article

Heterobifunctional proteomimetic polymers for targeted protein degradation

2025-03-12

Abstract excerpt

The burgeoning field of targeted protein degradation (TPD) has opened new avenues for modulating the activity of previously undruggable proteins of interest. To date, TPD has been dominated by small molecules containing separate linked domains for protein engagement and recruitment of cellular degradation machinery. The process of identifying active compounds has required tedious optimization and has been successf...

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Literature Corpus work: bce4a4e9-d3f8-5e4f-81b7-805d316145d0
DOI: 10.1101/2025.03.07.641543

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