Article

C-terminal amides mark proteins for degradation via SCF/FBXO31

2023-06-30

Abstract excerpt

During normal cellular homeostasis unfolded and mis-localized proteins are recognized and removed, preventing the build-up of toxic byproducts 1 . When protein homeostasis is perturbed during aging, neurodegeneration or cellular stress, proteins can accumulate several forms of chemical damage through reactive metabolites 2, 3 . Such modifications have been proposed to trigger the selective removal of chemically...

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Identifiers and source

Literature Corpus work: 12e13c95-b483-5a8d-b717-7b93c2464746
DOI: 10.1101/2023.06.29.547030

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