Article

A Mammalian High-Throughput Screen for AI-Designed Peptide-Guided Protein Degraders

2026-08-26

Abstract excerpt

Targeted protein degradation (TPD) offers a route to eliminate disease-driving proteins that remain inaccessible to conventional inhibitors. However, degrader discovery remains low-throughput, labor-intensive, and dependent on randomized libraries or non-human display systems, limiting functional selection in mammalian cells. Here, we present a high-throughput, human cell-based platform for screening peptide-guide...

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Literature Corpus work: 61b669d3-23ea-50c6-9359-4dddbdf7cdbd
DOI: 10.64898/2026.08.24.746873

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