Article

Generative AI Framework SynGlue for the Rational Design of Clinically relevant Protein Degraders

2025-09-02

Abstract excerpt

<h4>ABSTRACT</h4> The rational design of protein degraders, such as proteolysis-targeting chimeras (PROTACs), requires the simultaneous optimization of multiple molecular properties, a complex challenge that limits efficient discovery. Here, we introduce SynGlue, a generative artificial intelligence (AI) framework that addresses this challenge through two core modules: data-driven, leveraging large-scale protein-...

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Literature Corpus work: 68b5fad5-4f14-5853-80f3-c6eb2e17dbb3
DOI: 10.1101/2025.08.28.672835

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