Article

Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC

2021-03-09

Abstract excerpt

DNA-binding proteins including transcription factors (TFs) play essential roles in gene transcription and DNA replication and repair during normal organ development and pathogenesis of diseases such as cancer, cardiovascular disease and obesity, deeming to be a large repertoire of attractive therapeutic targets. However, this group of proteins are generally considered undruggable as they lack an enzymatic catalyti...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 36e1b198-3a88-5631-a90c-4a1c6878491d
DOI: 10.1101/2021.03.08.434493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTACDOI 10.1101/2021.03.08.434493Read

Targeting Undruggable Transcription Factors with PROTACs: Advances and PerspectivesSemantic proximity Read

Targeting the Undruggable: Recent Progress in PROTAC-Induced Transcription Factor DegradationSemantic proximity Read

PROTACs: Current and Future Potential as a Precision Medicine Strategy to Combat CancerSemantic proximity Read

Targeting the Interplay of Proteins through PROTACs for the Management of Cancer and Associated DisordersSemantic proximity Read

PROTAC’ing oncoproteins: targeted protein degradation for cancer therapySemantic proximity Read

RNA‐PROTACs: Degraders of RNA‐Binding ProteinsSemantic proximity Read

Structural Optimization of Decoy Oligonucleotide-Based PROTAC That Degrades the Estrogen ReceptorSemantic proximity Read

Chemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader Targeting NF-κBSemantic proximity Read

Expanding PROTACtable genome universe of E3 ligasesSemantic proximity Read

CRBN‐PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical ApplicationsSemantic proximity Read

OligoTRAFTACs: A Generalizable Method for Transcription Factor DegradationSemantic proximity Read

PROTACs: great opportunities for academia and industrySemantic proximity Read