Article

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD- associated Transcriptomic Networks and Pathology

2026-03-04

Abstract excerpt

<h4>SUMMARY</h4> In Huntington’s disease (HD), disease-driver genes are broadly expressed, but pathogenic players specific to vulnerable neurons remain poorly defined. Leveraging a previously defined mutant huntingtin (mHtt) CAG-length-associated gene network, we perturbed 115 module hub genes with heterozygous knockout (KO-het) to assess their striatal transcriptomic modifier effects in wildtype and Q140 HD mice...

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Literature Corpus work: 9e281f74-fe42-5a4b-b0ac-9755cb4ef537
DOI: 10.64898/2026.03.02.709091

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