Article

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons

2025-02-25

Abstract excerpt

<h4>Summary</h4> Huntington’s Disease (HD) is caused by a CAG repeat expansion in the gene encoding Huntingtin (HTT ) . While normal HTT function appears impacted by the mutation, the specific pathways unique to CAG repeat expansion versus loss of normal function are unclear. To understand the impact of the CAG repeat expansion, we evaluated biological signatures of HTT knockout ( HTT KO) versus those that occu...

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Literature Corpus work: 634b384c-979f-5c25-8ec1-d5a9d2465948
DOI: 10.1101/2025.02.24.639958

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