Article

Long somatic DNA-repeat expansion drives neurodegeneration in Huntington disease

2024-05-20

Abstract excerpt

Huntington Disease (HD) is a fatal genetic disease in which most striatal projection neurons (SPNs) degenerate. The central biological question about HD pathogenesis has been how the disease-causing DNA repeat expansion (CAG n ) in the huntingtin ( HTT ) gene leads to neurodegeneration after decades of apparent latency. Inherited HTT alleles with a longer CAG repeat hasten disease onset; the length of this rep...

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Literature Corpus work: 4c395382-170e-5da2-9756-4cfd21761596
DOI: 10.1101/2024.05.17.592722

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