Article

The Caudate Nucleus Undergoes Dramatic and Unique Transcriptional Changes in Human Prodromal Huntington’s Disease Brain

2019-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The mechanisms underlying degeneration of the specific neurons in the striatum of Huntingon’s Disease (HD) brain are currently unknown. The striatum is massively degenerated in late stage HD, making examination of post-mortem brain tissue from symptomatic individuals problematic. Striatal tissue is largely intact in the brains of asymptomatic HD positive (HD+) gene carriers, but these samples ar...

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Literature Corpus work: 365165f2-5004-5cfe-9d57-2f0eb76ad6d1
DOI: 10.1101/520312

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