Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics

6 Jun 2025

Abstract excerpt

Huntington's disease (HD) is marked by widespread cellular dysregulation. To understand disease mechanisms, we and others have utilized bulk and single-cell transcriptomics, which provide cell-type information but limited spatial information. We used 10× Genomics Visium spatial transcriptomics integrated with matched single-nuclei RNA sequencing (snRNA-seq) in the rapidly progressing HD R6/2 mouse brain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to RNA Research and Splicing
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40482637
DOI: 10.1016/j.neuron.2025.05.014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomicsPMID 40482637Read ↗

Single-nucleus RNA-seq reveals dysregulation of striatal cell identity due to Huntington’s disease mutationsSemantic proximity Read ↗

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations.Semantic proximity Read ↗

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons.Semantic proximity Read ↗

Integrated profiling of single cell epigenomic and transcriptomic landscape of Parkinson’s disease mouse brainSemantic proximity Read ↗

Quantitative gene expression profiling of mouse brain regions reveals differential transcripts conserved in human and affected in disease modelsSemantic proximity Read ↗

Temporal single-cell atlas of full-length Huntington’s disease mouse model defines stage-specific signatures of corticostriatal dysfunctionSemantic proximity Read ↗

Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolismSemantic proximity Read ↗

High resolution time-course mapping of early transcriptomic, molecular and cellular phenotypes in Huntington's disease CAG knock-in mice across multiple genetic backgrounds.Semantic proximity Read ↗

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington’s diseaseSemantic proximity Read ↗

Single Nucleus Transcriptome Data from Alzheimer’s Disease Mouse Models Yield New Insight into PathophysiologySemantic proximity Read ↗

snRNA-seq of Huntington’s disease mice reveals vulnerability profiles of cortical cell typesSemantic proximity Read ↗

The cell type composition of the adult mouse brain revealed by single cell and spatial genomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.