Article

Polygenic Health Index, General Health, Pleiotropy, Embryo Selection and Disease Risk

2022-06-21

Abstract excerpt

We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by population-level estimates of impact on life expectancy. We validate this index in odds ratios and selection experiments using unrelated individuals and siblings (pairs and trios) f...

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Literature Corpus work: b1b2e3ee-9a17-50e7-9a4a-50629d215b5e
DOI: 10.1101/2022.06.15.22276102

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