Article

Within- and Between-Family Validation of Nine Polygenic Risk Scores Developed in 1.5 Million Individuals: Implications for IVF, Embryo Selection, and Reduction in Lifetime Disease Risk

2025-10-28

Abstract excerpt

Polygenic risk scores (PRSs) can reduce lifetime disease risk by guiding embryo selection during in vitro fertilization (IVF). We performed genome-wide association meta-analyses totaling ∼1.5 million individuals to construct state-of-the-art PRSs for nine diseases: Alzheimer’s disease, breast cancer, coronary artery disease, endometriosis, hypertension, prostate cancer, rheumatoid arthritis, type 1 diabetes, and t...

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Literature Corpus work: 48f78dca-b64d-5064-ace9-acfe4fab66b6
DOI: 10.1101/2025.10.24.25338613

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