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Polygenic Health Index, General Health, and Pleiotropy: Sibling Analysis and Disease Risk Reduction

28 Oct 2022

Abstract excerpt

We construct a polygenic health index as a weighted sum of polygenic risk scores for 20 major disease conditions, including, e.g., coronary artery disease, type 1 and 2 diabetes, schizophrenia, etc. Individual weights are determined by population-level estimates of impact on life expectancy. We validate this index in odds ratios and selection experiments using unrelated individuals and siblings (pairs and trios)...

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PMID: 36307513
DOI: 10.1038/s41598-022-22637-8

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