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Article

Discovery and implications of polygenicity of common diseases.

Science (New York, N.Y.) - 24 Sept 2021

Visscher Peter M, Yengo Loic, Cox Nancy J, Wray Naomi R

Abstract excerpt

The sequencing of the human genome has allowed the study of the genetic architecture of common diseases: the number of genomic variants that contribute to risk of disease and their joint frequency and effect size distribution. Common diseases are polygenic, with many loci contributing to phenotype, and the cumulative burden of risk alleles determines individual risk in conjunction with environmental factors. Most...

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Identifiers

PMID: 34554790
DOI: 10.1126/science.abi8206
PMCID: PMC9945947

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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