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Project Score database: a resource for investigating cancer cell dependencies and prioritizing therapeutic targets

14 Oct 2020

Abstract excerpt

CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic mechanisms and to identify promising therapeutic targets. The Project Score database (https://score.depmap.sanger.ac.uk/) uses genome-wide CRISPR-Cas9 dropout screening data in hundreds of highly annotated cancer cell models to identify genes required for cell fitness and prioritize novel oncology targets. The Project Score...

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PMID: 33068406
DOI: 10.1093/nar/gkaa882

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