Article

Coupling of NOD2 to GIV is Required for Bacterial Sensing

2022-04-27

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> Sensing of pathogens by Nucleotide oligomerization domain (NOD)-like 2 receptor (NOD2) induces a protective inflammatory response that coordinates bacterial clearance. Polymorphisms in NOD2 impair bacterial clearance, leading to chronic gut inflammation in Crohn’s disease (CD) via mechanisms that remain incompletely understood. We identify GIV/Girdin (CCDC88A) as a NOD2-interactor that s...

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Literature Corpus work: b18e6314-f648-5427-b24b-55981f5f4d0d
DOI: 10.1101/2022.04.26.489574

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