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Article

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.

Nature medicine - 1 Jan 2010

Cooney Rachel, Baker John, Brain Oliver, Danis Benedicte, Pichulik Tica, Allan Philip, Ferguson David J P, Campbell Barry J, Jewell Derek, Simmons Alison

Abstract excerpt

Nucleotide-binding oligomerization domain-containing-2 (NOD2) acts as a bacterial sensor in dendritic cells (DCs), but it is not clear how bacterial recognition links with antigen presentation after NOD2 stimulation. NOD2 variants are associated with Crohn's disease, where breakdown in self-recog...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 19966812
DOI: 10.1038/nm.2069

Genes

NOD2
ATG5
ATG7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19966812-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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