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Article

TLR Signaling in the Gut in Health and Disease

1 Apr 2005

Abstract excerpt

The human intestine has evolved in the presence of diverse enteric microflora. TLRs convert the recognition of pathogen-associated molecules in the gut into signals for anti-microbial peptide expression, barrier fortification, and proliferation of epithelial cells. Healing of injured intestinal epithelium and clearance of intramucosal bacteria require the presence of intact TLR signaling. Nucleotide...

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PMID: 15814663
DOI: 10.4049/jimmunol.174.8.4453

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