Article

Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis

2025-01-24

Abstract excerpt

<h4>ABSTRACT</h4> Single-cell studies have revealed that intestinal macrophages maintain gut homeostasis through the balanced actions of reactive (inflammatory) and tolerant (non-inflammatory) subpopulations. How such balance is impaired in inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), remains unresolved. Here, we define colon-specific macrophage states and reveal...

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Literature Corpus work: 546cd204-6648-5370-8ebc-260e9a21c5d8
DOI: 10.1101/2025.01.21.634180

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