Article

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

2020-08-30

Abstract excerpt

Sensing of pathogens by Toll-like receptor 4 (TLR4) induces an inflammatory response; controlled responses confer immunity but uncontrolled responses cause harm. Here we define how a multi-modular scaffold, GIV (a.k.a Girdin) titrates such inflammatory response in macrophages. Upon challenge with either live microbes or microbe-derived lipopolysaccharides (LPS, a ligand for TLR4), macrophages with GIV mount a more...

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Identifiers and source

Literature Corpus work: 9b481085-3f35-52ab-b66a-e588c7fb2d9a
DOI: 10.1101/2020.08.29.273516

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