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Article

Interactions between Nod-Like Receptors and Intestinal Bacteria

1 Jan 2013

Abstract excerpt

Nucleotide oligomerization domain (Nod)-like Receptors (NLRs) are cytosolic sensors that mediate the activation of Caspase-1 and the subsequent processing and secretion of the pro-inflammatory cytokines IL-1β and IL-18, as well as an inflammatory cell death termed pyroptosis. While a multitude of bacteria have been shown to activate one or more NLRs under in vitro conditions, the exact impact of NLR activation...

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Identifiers

PMID: 24381573
DOI: 10.3389/fimmu.2013.00462

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