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NOD2-Related Multisystem Inflammatory Disorders and Recent Advances.

Current rheumatology reports - 12 Feb 2026

Wu Di, Matsuda Tomoko, Xie Danielle, Shen Min, Dhar Atika, Davis John M, Shen Bo, Kambe Naotomo, Strober Warren, Yao Qingping

Abstract excerpt

PURPOSE OF REVIEW: Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular innate immune sensor. Its functions have been extensively studied. Variants in the NOD2 gene are associated with several human diseases. This report provides a comprehensive review of these diseases and biomedical and immunological roles of NOD2. RECENT FINDINGS: Blau syndrome is an autosomal dominant...

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Source

Identifiers

PMID: 41678017
DOI: 10.1007/s11926-026-01212-4

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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