Article

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor Microenvironments

2024-04-27

Abstract excerpt

Several classification systems have been developed to define tumor subtypes in colorectal cancer (CRC). One system proposes that tumor heterogeneity derives in part from distinct cancer stem cell populations that co-exist as admixtures of varying proportions. However, the lack of single cell resolution has prohibited a definitive identification of these types of stem cells and therefore any understanding of how ea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c8106b98-1a80-55c4-aa38-4ad3733a4c54
DOI: 10.1101/2024.04.25.591144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor MicroenvironmentsDOI 10.1101/2024.04.25.591144Read

Single-Cell Transcriptome Analysis Reveals Heterogeneity and Convergence of the Tumor Microenvironment in CRCSemantic proximity Read

Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA SequencingSemantic proximity Read

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease RelapseSemantic proximity Read

Revealing unidentified heterogeneity in different epithelial cancers using heterocellular subtype classificationSemantic proximity Read

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasiaSemantic proximity Read

The SW480 cell line as a model of resident and migrating colon cancer stem cellsSemantic proximity Read

Single-cell transcriptome analysis reveals SOX9 mutation-driven tumor stemness and microenvironment remodeling through the COL1A1-CD44 axis in colorectal cancer.Semantic proximity Read

Intestinal stem cells and the colorectal cancer microenvironment.Semantic proximity Read

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAomeSemantic proximity Read

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancerSemantic proximity Read

Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and TelomeresSemantic proximity Read

Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted TherapiesSemantic proximity Read