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CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington’s Disease, Including Genetic Modifiers of Neuronal Development and Morphology

2025-02-20

Abstract excerpt

Genomic screens and GWAS are powerful tools for identifying disease-modifying genes, but it is often challenging to understand the pathways by which these genes function. Here, we take an integrated approach that combines network analysis and an imaging-based pooled genetic perturbation study to examine modifiers of Huntington’s disease (HD). The computational analysis highlighted several genes in a subnetwork enr...

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Literature Corpus work: b1301332-ea68-578e-9f31-61d95076e094
DOI: 10.1101/2025.02.19.639023

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CellPHIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington’s Disease, Including Genetic Modifiers of Neuronal Development and MorphologyDOI 10.1101/2025.02.19.639023Read

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