Article
Human intellectual disability genes form conserved functional modules in Drosophila.
PLoS genetics - 1 Oct 2013
Oortveld Merel A W, Keerthikumar Shivakumar, Oti Martin, Nijhof Bonnie, Fernandes Ana Clara, Kochinke Korinna, Castells-Nobau Anna, van Engelen Eva, Ellenkamp Thijs, Eshuis Lilian, Galy Anne, van Bokhoven Hans, Habermann Bianca, Brunner Han G, Zweier Christiane, Verstreken Patrik, Huynen Martijn A, Schenck Annette
Abstract excerpt
Intellectual Disability (ID) disorders, defined by an IQ below 70, are genetically and phenotypically highly heterogeneous. Identification of common molecular pathways underlying these disorders is crucial for understanding the molecular basis of cognition and for the development of therapeutic intervention strategies. To systematically establish their functional connectivity, we used transgenic RNAi to target...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.