Article

The evolutionary potential of the influenza A virus hemagglutinin is highly constrained by intersegment epistasis

2022-05-19

Abstract excerpt

The ongoing antigenic evolution of the influenza A virus (IAV) hemagglutinin (HA) gene limits efforts to effectively control the spread of the virus in the human population through vaccination. The factors that influence and constrain the evolutionary potential of the HA gene remain poorly understood. Efforts to understand the mechanisms that govern HA antigenic evolution typically examine the HA gene in isolation...

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Literature Corpus work: b1028876-c38d-5a5f-aee8-4fdfb47cb64b
DOI: 10.1101/2022.05.19.492711

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