Article

Coordinated Evolution of Influenza A Surface Proteins

2014-08-20

Abstract excerpt

Surface proteins hemagglutinin (HA) and neuraminidase (NA) of the human influenza A virus evolve under selection pressure to escape the human adaptive immune response and antiviral drug treatments. In addition to these external selection pressures, some mutations in HA are known to affect the adaptive landscape of NA, and vice versa, because these two proteins are physiologically interlinked. However, the extent t...

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Literature Corpus work: b28c8587-17fd-57ca-a38c-0464b7e8c3f3
DOI: 10.1101/008235

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