Article

Prevalence and mechanisms of evolutionary contingency in human influenza H3N2 neuraminidase

2022-02-24

Abstract excerpt

<h4>ABSTRACT</h4> Neuraminidase (NA) of human influenza H3N2 virus has evolved rapidly and been accumulating mutations for more than half-century. However, biophysical constraints that govern the evolutionary trajectories of NA remain largely elusive. Here, we show that among 70 natural mutations that are present in the NA of a recent human H3N2 strain, >10% are deleterious for an ancestral strain. By mapping the...

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Literature Corpus work: db921ade-dcc8-5179-b764-22e69e6a38da
DOI: 10.1101/2022.02.24.481718

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