Article

Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza hemagglutinin

2025-05-24

Abstract excerpt

The evolution of human influenza virus hemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability. Epistasis shapes this evolution, as an antigenic mutation that is deleterious in one genetic background may become tolerated in another. However, the extent to which epistasis can alleviate pleiotropic conflicts bet...

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Literature Corpus work: 21aebebe-db00-5380-962e-873cf7aa7d2d
DOI: 10.1101/2025.05.24.655919

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