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Article

Pleiotropic mutational effects on function and stability constrain the antigenic evolution of influenza haemagglutinin.

Nature ecology & evolution - 1 Mar 2026

Yu Timothy C, Kikawa Caroline, Dadonaite Bernadeta, Loes Andrea N, Englund Janet A, Bloom Jesse D

Abstract excerpt

The evolution of human influenza virus haemagglutinin (HA) involves simultaneous selection to acquire antigenic mutations that escape population immunity while preserving protein function and stability. Epistasis shapes this evolution, as an antigenic mutation that is deleterious in one genetic background may become tolerated in another. However, the extent to which epistasis can alleviate pleiotropic conflicts...

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Share to Epistasis, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Pleiotropy

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza, Human

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Source

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Identifiers

PMID: 41326606
DOI: 10.1038/s41559-025-02895-1
PMCID: PMC12758803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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