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Coordinated Evolution of Influenza A Surface Proteins

6 Aug 2015

Abstract excerpt

The surface proteins hemagglutinin (HA) and neuraminidase (NA) of human influenza A virus evolve under selection pressures to escape adaptive immune responses and antiviral drug treatments. In addition to these external selection pressures, some mutations in HA are known to affect the adaptive landscape of NA, and vice versa, because these two proteins are physiologically interlinked. However, the extent to which...

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PMID: 26247472
DOI: 10.1371/journal.pgen.1005404

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