Article
A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site.
Nature communications - 28 Mar 2018
Wu Nicholas C, Thompson Andrew J, Xie Jia, Lin Chih-Wei, Nycholat Corwin M, Zhu Xueyong, Lerner Richard A, Paulson James C, Wilson Ian A
Abstract excerpt
The hemagglutinin (HA) receptor-binding site (RBS) in human influenza A viruses is critical for attachment to host cells, which imposes a functional constraint on its natural evolution. On the other hand, being part of the major antigenic sites, the HA RBS of human H3N2 viruses needs to constantly mutate to evade the immune system. From large-scale mutagenesis experiments, we here show that several of the natural...
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