Article

Antigenic evolution of human influenza H3N2 neuraminidase is constrained by charge balancing

2021-07-12

Abstract excerpt

As one of the main influenza antigens, neuraminidase (NA) in H3N2 virus has evolved extensively for more than 50 years due to continuous immune pressure. While NA has emerged as an effective vaccine target recently, biophysical constraints on the antigenic evolution of NA remain largely elusive. Here, we apply deep mutational scanning to characterize the local fitness landscape in an antigenic region of NA in six...

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Literature Corpus work: 40ef97b7-f5d1-5966-a90f-44a8e50b3985
DOI: 10.1101/2021.07.10.451918

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